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Weapon P.R.I.M.E. is a group of fictional superhuman operatives appearing in American comic books published by Marvel Comics. They are usually depicted as acting under the authority of Canada's Department K. They became Canada's preeminent superhero team after the demise of Alpha Flight. Their first appearance and mission was in X-Force #11-14. As revealed in the Official Handbook of the Marvel Universe: A-Z, "P.R.I.M.E." stands for "PRototype Induced Mutation Echelon."